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Effect ofPlasmodium berghei infection on benzoic acid metabolism in mice |
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| Authors: | T S Emudianughe Q D Bickle M G Taylor B Andrews |
| Institution: | (1) Department of Clinical Pharmacology, Faculty of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria;(2) Department of Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, AL4OYQ St. Albans, England |
| Abstract: | Summary The metabolism of benzoic acid was studied inPlasmodium berghei infected mice both in vitro and in vivo. Results of in vitro studies showed a considerable decrease in the ability of the infected liver to detoxify benzoic acid by hippuric acid formation. The in vivo study showed that hippuric acid formation decreases with increasing parasitemia and the emergence of benzoyl-glucoronide. This new pathway stops operating with further increase in parasitemia. |
| Keywords: | Mouse liver malaria infection benzoic acid detoxification glucuronic acid conjugation hippuric acid |
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