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Modulation of protein kinases and phosphoprotein phosphatases by a small acidic protein from bovine brains |
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| Authors: | W N Kuo L P Liu M A Rahmani |
| Abstract: | A small, acidic and heat-stable protein was purified from bovine brains by column chromatography on DEAE-cellulose, Bio-Gel HTP, Affi-Gel phenothiazine and Sephadex G-75. This protein stimulates megamodulin-dependent protein kinase I from brains and phosphoprotein phosphatases from either brain or yeast. However, it inhibits cyclic AMP-dependent protein kinases from skeletal muscle. |
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