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| 超声波辅助脂肪酶催化拆分丁酸环氧丙酯 | |
| 引用本文： | 王佳欣,孙若溪,荀二娜,张爱军,王任,魏晓飞,王磊,王智.超声波辅助脂肪酶催化拆分丁酸环氧丙酯[J].吉林大学学报(理学版),2011,49(4):782-786. |
| 作者姓名： | 王佳欣 孙若溪 荀二娜 张爱军 王任 魏晓飞 王磊 王智 |
| 作者单位： | 1. 吉林大学 分子酶学工程教育部重点实验室, 长春 130012; 2. 吉林大学 生命科学学院, 长春 130012 |
| 基金项目： | 国家自然科学基金，吉林大学基本科研业务费项目 |
| 摘 要： | 利用超声波辅助脂肪酶催化拆分丁酸环氧丙酯,考察了超声发生装置、超声处理方法、超声功率及超声温度等反应条件对酶促拆分反应的影响,筛选得到最适反应条件.结果表明,在最适反应条件下,超声作用可以使酶活提高近4.3倍,立体选择性提高5倍. |
| 关 键 词： | 超声 脂肪酶 丁酸环氧丙酯 拆分 |
| 收稿时间： | 2010-10-15 |
Ultrasound-Promoted Resolution of (R, S)-Glycidyl Butyrate Catalyzed by Lipase |
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| WANG Jia-xin,SUN Ruo-xi,XUN Er-na,ZHANG Ai-jun,WANG Ren,WEI Xiao-fei,WANG Lei,WANG Zhi.Ultrasound-Promoted Resolution of (R, S)-Glycidyl Butyrate Catalyzed by Lipase[J].Journal of Jilin University: Sci Ed,2011,49(4):782-786. | |
| Authors: | WANG Jia-xin SUN Ruo-xi XUN Er-na ZHANG Ai-jun WANG Ren WEI Xiao-fei WANG Lei WANG Zhi |
| Institution: | 1. Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin University,Changchun 130012, China| 2. College of Life Science, Jilin University, Changchun 130012, China |
| Abstract: | The ultrasound was used to promote the resolution of glycidyl butyrate catalyzed by lipase. The effects of ultrasound source, ultrasonic processing method, power and temperature were also investigated to obtain theoptimum reaction conditions. Under the optimum conditions, the enzyme activity of BSL2 in the resolution of glycidyl butyrate was enhanced by about 4.3 fold and the enantioselectivity increased by about 5.0 fold. |
| Keywords: | ultrasound lipase glycidyl butyrate resolution |
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