江西吉安地区高尿酸血症患病情况及危险因素分析

目的了解江西省吉安市人群高尿酸血症患病特点及相关危险因素分析。方法在2018年1月1日至7月30日期间于吉安医院体检的人群中,随机抽取1000名16岁及以上吉安常住居民体检者作为研究样本,统计不同年龄段、不同性别者高尿酸血症的患病率,并应用Logistic回归模型进行高尿酸血症相关危险因素分析。结果1000名体检者中高尿酸血症患病率为23.3%(95%CI20.68%～25.92%),其中男性患病率28.08%(95%CI24.44%～31.73%)明显高于女性患病率16.59%(95%CI13.01%～20.16%),具有统计学意义(P0.001)。多因素logistic回归分析显示收缩压(OR=1.014,95%CI=1.005-1.023,P=0.002)、甘油三酯(OR=1.263,95%CI=1.106-1.443,P=0.001)、低密度脂蛋白(OR=1.376, 95%CI=1.026-1.845,P=0.033)升高,肾小球滤过率(OR=0.985,95%CI=0.977-0.993,P0.001)和高密度脂蛋白(OR=0.612,95%CI=0.402-0.931,P=0.022)降低是高尿酸血症的独立危险因素。结论在江西省吉安地区人群中,收缩压、甘油三酯、低密度脂蛋白升高,肾小球滤过率和高密度脂蛋白降低是高尿酸血症的独立危险因素。积极控制血压、血脂,保护肾脏功能,对于预防和治疗高尿酸血症具有重要意义。

PREVALENCE AND RISK FACTORS OF HYPERURICEMIA IN JI'AN OF JIANGXI PROVINCE

Objective:To survey the prevalence of hyperuricemia of residents in Ji''an City, Jiangxi Province and investigate the risk factors of hyperuricemia. Methods:We collected 1000 samples from adult residents, who were received physical examination from 1 January to 30 July 2018 in Ji''an Hospital. Counting the prevalence in different ages and different genders, logistic regression model was used to find out the risk factors associated with hyperuricemia. Results:The prevalence of hyperuricemia was 23.3% (95% CI 20.68%-25.92%). And the prevalence of hyperuricemia in male (28.08%, 95% CI 24.44%-31.73%) was higher than that in female (16.59%, 95% CI 13.01%-20.16%) (P<0.001). After multivariate logistic regression analysis (multiple adjusted models), increased systolic pressure (OR=1.014, 95% CI=1.005-1.023, P=0.002), triglyceride (OR=1.263, 95% CI=1.106-1.443, P=0.001), low density lipoprotein cholesterol (OR=1.376, 95% CI=1.026-1.845, P=0.033), decreased glomerular filtration rate (OR=0.985, 95% CI=0.977-0.993, P<0.001) and high density lipoprotein cholesterol (OR=0.612, 95% CI=0.402-0.931, P=0.022) were independent risk factors for hyperuricemia. Conclusion:Increased systolic pressure,triglyceride, low density lipoprotein cholesterol and decreased glomerular filtration rate and high density lipoprotein cholesterol were independent risk factors for hyperuricemia in the residents of Ji''an City. Controlling blood pressure, blood lipids, and protecting kidney function are important for the prevention and treatment of hyperuricemia.