| 鱼类免疫因子Prx 1和Prx 2的研究进展 |
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| 引用本文： | 郑琦,邹子鸿,蔡佳,简纪常.鱼类免疫因子Prx 1和Prx 2的研究进展[J].广西科学院学报,2019,35(3):172-175,184. |
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| 作者姓名： | 郑琦 邹子鸿 蔡佳 简纪常 |
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| 作者单位： | 广东海洋大学水产学院,广东湛江,524088;广东海洋大学水产学院,广东湛江,524088;广东海洋大学水产学院,广东湛江,524088;广东海洋大学水产学院,广东湛江,524088 |
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| 基金项目： | 国家自然科学基金项目（31302226，31572651）和广东海洋大学优秀硕士学位论文培育项目（201833）资助。 |
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| 摘 要： | Peroxiredoxin 1(Prx 1)和Peroxiredoxin 2(Prx 2)是脊椎动物中一种保守的免疫因子,在鱼类的非特异性免疫中扮演重要角色,也叫作自然杀伤增强因子(Natural killer enhancing factor,NKEF A/B)。两类蛋白的N端和C端各含有一个活性半胱氨酸位点。Prx 1和Prx 2能清除机体活性氧(ROS)如H2O2,同时还参与鱼体的抗病免疫。本文对鱼类Prx 1和Prx 2的结构、抗氧化机制、生物学功能进行综述性介绍。
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| 关 键 词： | 鱼类 免疫因子 Prx 1 Prx 2 抗氧化蛋白 结构 功能 |
Advance in Peroxiredoxin 1 and Peroxiredoxin 2 of Teleost Immune Factors |
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| ZHENG Qi,ZOU Zihong,CAI Jia and JIAN Jichang.Advance in Peroxiredoxin 1 and Peroxiredoxin 2 of Teleost Immune Factors[J].Journal of Guangxi Academy of Sciences,2019,35(3):172-175,184. |
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| Authors: | ZHENG Qi ZOU Zihong CAI Jia and JIAN Jichang |
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| Institution: | College of Fishery, Guangdong Ocean University, Zhanjiang, Guangdong, 524088, China,College of Fishery, Guangdong Ocean University, Zhanjiang, Guangdong, 524088, China,College of Fishery, Guangdong Ocean University, Zhanjiang, Guangdong, 524088, China and College of Fishery, Guangdong Ocean University, Zhanjiang, Guangdong, 524088, China |
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| Abstract: | Peroxiredoxin 1 (Prx 1) and Peroxiredoxin 2 (Prx 2) are conserved immune factors in vertebrates and play an important role in teleost innate immunity,which are also known as Natural Killer Enhancing Factor (NKEF A/B).Both types of proteins contain an active cysteine site at the N-terminus and C-terminus,respectively.Prx 1 and Prx 2 can eliminate reactive oxygen species (ROS) such as H2O2 and also participate in anti-pathogeny immune responses.In this paper,the structure,antioxidant mechanism and biological function of fish Prx 1 and Prx 2 were reviewed. |
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| Keywords: | fish teleost peroxiredoxin 1 peroxiredoxin 2 immunity structure function |
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