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Heating effect and biocompati bility of bacteri almagnetoso mes as potential materials used in magnetic fluid hyperthermia
Authors:Rui-ting Liu  Jie Liu  Jie-qiong Tong  Tao Tang  Wei-Chao Kong  Xiao-wen Wang  Ying Li  Jin-tian Tang
Affiliation:1. Key Laboratory of Particle & Radiation Imaging(Tsinghua University), Ministry of Education,Department of Engineering Physics, Tsinghua University, Beijing 100084, China
2. Key Laboratory of Particle & Radiation Imaging(Tsinghua University), Ministry of Education,Department of Engineering Physics, Tsinghua University, Beijing 100084, China;Department of Pharmaceutics, Beijing University of Chinese Medicine, Beijing 100102, China
3. Key Laboratory of Particle & Radiation Imaging(Tsinghua University), Ministry of Education,Department of Engineering Physics, Tsinghua University, Beijing 100084, China;State Key Laboratories for Agrobiotechnology and College of Biological Sciences, China Agricultural University,Beijing 100083, China
4. State Key Laboratories for Agrobiotechnology and College of Biological Sciences, China Agricultural University,Beijing 100083, China
Abstract:Magnetic fluid hyperthermia (MFH) promises to be a viable alternative in the treatment of localized cancerous tumors. The treatment consists of introducing nanoparticles as energy absorbent agents in tumor tissue under an oscillating magnetic field, where nanoparticles dissipate energy in the form of heat, causing a localized rise in the temperature and tumor cell death. Traditional magnetic fluid under study is artificial magnetic nanoparticles. This work seeks to introduce the new natural biolog ic magnetic material bacterial magnetosomes (BMs) to be used in MFH. Properties of magnetosomes and chemically synthesized magnetic nanoparticles (MNPs), such as morphology, magnetic properties and their heating effects under magnetic field were compared. Cytotoxicity studies using human breast cancer cells MCF-7 indicated that cell viability could be significantly decreased by the heat derived from BMs and MNPs under alternative magnetic field. Biocompatibility of BMs and MNPs was compared in terms of evaluating their acute toxicit y in mice and their decomposition abilities in vitro , and it showed that magnetosomes exhibit a lower toxicit y. These finding s provide evidence for beneficial activities of magnetosomes in MFH and support the continued investigation of it to be applied in biomedicine.
Keywords:Magnetosome   Synthesized magnetic nanoparticles  Magnetic fluid hyperthermia   Properties   Biocompatibility
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