(1) Department of Neurosurgery, Academic Hospital, Uppsala, (Sweden);(2) Department of Neurosurgery, Sahlgren Hospital, S-41345 Göteborg, (Sweden);(3) Department of Clinical Immunology, Institute of Microbiology, Göteborg, (Sweden)
Abstract:
Summary Subarachnoidal hemorrhage (SAH) from an arterial aneurysm is often followed by vasospasm which may lead to severe or even fatal ischemic brain lesions. The cause of the vasospasm is still unknown. In the present study it is shown that patients with SAH and roentgenological and/or clinical vasospasm have a significantly higher frequency (52%) of circulating immune complexes in the blood than patients with SAH without spasm (9%). This finding indicates that the vasospasm following SAH may be elicited via an immunoreaction.