氢化诺卜醛环状缩醛类化合物的合成及其抑菌活性

以氢化诺卜醇为原料，经氯铬酸吡啶（PCC）氧化合成氢化诺卜醛，再由氢化诺卜醛与乙二醇、1，2-丙二醇和1，3-丙二醇分别发生缩合反应，合成了氢化诺卜醛乙二醇缩醛（2a）、氢化诺卜醛1，2-丙二醇缩醛（2b）、氢化诺卜醛1，3-丙二醇缩醛（2c），其结构经 FT-IR、EI-MS、1 H NMR、13 C NMR 确认，3种化合物均为新化合物.以枇杷炭疽病菌（Cdletotrichum gloeosporioides）、油茶炭疽病菌（ Colletotrichum gloeospori-oides）、辣椒疫病菌（Phytophthora capsici）、水稻纹枯病菌（hizocitonia solani）、水稻稻瘟病菌（Magnaporthe grisea）、莴苣菌核病菌（Sclerotinia sclerotiorum）为实验对象，开展抑菌活性测定，结果表明:在100 mg·L -1浓度下，3种化合物对6种病原菌均具有一定的抑菌活性，化合物2c 对辣椒疫病菌抑菌率达到100；，化合物2b 对水稻纹枯病菌抑菌率达到98.78；，化合物2a 和2c 对油茶炭疽病菌、2b 对莴苣菌核、2c 对水稻纹枯病菌的抑菌率均在80；以上.

The Synthesis and Antifungal Activity of Cyclic Acetal Hydronopic Aldehyde Derivatives

The hydronopic aldehyde was synthesized from hydronopol via pyridinium chlorochromate(PCC)oxida-tion. Then the hydronopic aldehyde reacted with aldehyde,glycol,1,2-propanediol and 1,3-propanediol cyclic. Finally,three new derivatives,hydronopic aldehyde 1,2-ethandiol acetal(2a),hydronopic aldehyde 1,2-propanediol acetal(2b),hydronopic aldehyde 1,3-propanediol acetal(2c)were synthesized. The structures of all compounds were confirmed by IR,ESI-MS,1 H NMR and 13 C NMR. The compounds were used of carrying out preliminary bioas-say tests,and the Cdletotrichum gloeosporioides,Colletotrichum gloeosporioides,Phytophthora capsici,Rhizocitonia so-lani,Magnaporthe grisea and Sclerotinia sclerotiorum as the experimental subject. Antifungal activity showed that all the compounds exhibit some fungicidal activity against six fungi tested at the concentration of 100 mg·L - 1 ,among them,2a showed 100； inhibition rate against Phytophthora capsici,the inhibition rate of 2b against Rhizoctorzia so-lani were 98. 78； ,the inhibition rate of 2a and 2c against Colletotrichum gloeosporioides,2b against Sclerotinia scle-rotiorum,2c against Rhizoctorzia solani were above 80； .