基于有效极矩法的非球形细胞高阶介电泳力研究

细胞承受介电泳力的运动模拟在微控研究占据着举足轻重的地位.传统细胞介电泳力的求解理想化地将细胞看作球体进行计算.近似求解忽略了细胞的高阶介电泳力作用,导致分子动力学仿真结果与实验观测存在较大误差.基于有效极矩方法研究了椭球和红细胞的高阶介电泳力.研究发现Pohl介电泳力表达式在球体计算中依旧有效.从1阶至9阶的高阶极子曲线来看,椭球和红细胞奇数项系数非零,且与它们的形状密切相关.中间凹陷两端凸起的红细胞介电泳力大小近似于偏心率1∶5型椭球.研究结果与Ogbi等学者的仿真完全相符.

Research on High-Order Dielectrophoresis for Non-Spherical Cell Using Effective Moment Method

Simulation of cells exerted by the dielectrophoresis plays an important role in the micro-manipulation fields. Traditional solution to dielectrophoretic force experienced cell is ideally considered as a regular sphere calculation. The effect of high-order dielectrophoretic forces are often neglected， which will cause greater error between molecular dynamics and experimental observation. Therefore， the effective moment method was used to solve high-order dielectrophoresis for both ellipsoid and erythrocyte in this paper. It is effective for classical Pohl expression to predict spherical cell exerted by dielectrophoresis. However， odd numerical moments are closely related to their shape such as ellipsoids and erythrocyte are non-zero from 1 to 9 order dipole moments. The dielectrophretic force of erythrocyte similar to oblate spheroid with indented side approximates the ellipsoid with eccentricity ratio 1∶5. The results were in good agreement with Ogbi’s reports.