| 野木瓜注射液对大鼠外周痛觉信息传导的影响 |
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| 引用本文： | 刘向明,郭学芹,陈素.野木瓜注射液对大鼠外周痛觉信息传导的影响[J].中南民族大学学报(自然科学版),2010,29(1):45-50,61. |
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| 作者姓名： | 刘向明 郭学芹 陈素 |
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| 作者单位： | 中南民族大学,民族药物神经药理研究室,武汉,430074 |
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| 基金项目： | 国家自然科学基金资助项目，国家民委自然科学基金资助项目 |
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| 摘 要： | 对完整Wistar大鼠模型,应用微电极细胞外记录技术,观察了在坐骨神经处分别加入10%,25%,50%,75%和95%的野木瓜注射液前后,电刺激大鼠坐骨神经诱发的脊髓背角广动力范围神经元放电活动的变化.结果表明:野木瓜注射液在坐骨神经处加药时能降低大鼠脊髓背角广动力范围神经元的诱发放电频率和幅度(P0.05),并具有浓度依赖性,这与野木瓜注射液对离体背根神经节细胞产生的效应是一致的.野木瓜注射液可以在外周水平上阻滞痛觉信息的传导,这可能是其产生镇痛作用的原因之一.
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| 关 键 词： | 野木瓜注射液 细胞外记录 广动力范围神经元 坐骨神经 |
Effects of Injection Stauntoniae on the Conduction of Peripheral Pain Message in Rats |
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| Liu Xiangming,Guo Xueqin,Chen Su.Effects of Injection Stauntoniae on the Conduction of Peripheral Pain Message in Rats[J].Journal of South-Central Univ for,2010,29(1):45-50,61. |
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| Authors: | Liu Xiangming Guo Xueqin Chen Su |
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| Institution: | Liu Xiangming,Guo Xueqin,Chen Su (Institute of Neuropharmacological Research on National Drug,South-central University for Nationalities,Wuhan 430074,China) |
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| Abstract: | Single extracellular microelectrode recordings were used to observe the effects on the wide-dynamic range(WDR) discharge frequency after the administration of different doses(10 %,25 %,50 %,75 %,95 %)of injection stauntoniae(IS) on the sciatic nerve of the hind paw of Wistar rats.It was demonstrated that the WDR neuron evoked discharge frequency and magnitude with electrical stimulation on sciatic nerve was significantly reduced in a dose-dependent way(P<0.05) after the administration of IS ,which conformed... |
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| Keywords: | injection stauntoniae extracellular recordings wide-dynamic range neuron sciatic nerve |
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