Dissection of cytotoxic and helper T cell responses |
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Authors: | K Schepers R Arens T N M Schumacher |
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Institution: | (1) Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands |
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Abstract: | Cytotoxic (CD8+) and helper (CD4+) T cells play a crucial role in resolving infections by intracellular pathogens. The development of technologies to visualize
antigen-specific T cell responses in mice and men over the past decade has allowed a dissection of the formation of adaptive
T cell immunity. This review gives a brief overview of the currently used detection techniques and possible future additions.
Furthermore, we discuss our current understanding of the formation of antigen-specific T cell responses, with particular attention
to the similarities and differences in CD4+ and CD8+ T cell responses, the functional heterogeneity within responder T cell pools and the regulation of CD8+ T cell responses by dendritic cells and CD4+ helper T cells.
Received 16 June 2005; received after revision 2 August 2005; accepted 15 August 2005 |
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Keywords: | CD4+ T lymphocytes CD8+ T lymphocytes T cell memory antigen presenting cells dendritic cells infection T cell differentiation T cell migration |
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