|
|||||
|
|
Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy |
|
| Authors: | SongTing Shi David J. J. de Gorter Willem M. H. Hoogaars Peter A. C. ’t Hoen Peter ten Dijke |
| Affiliation: | 1. Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Centre, Building 2, Room R-02-022, Postzone S-1-P, PO Box 9600, Einthovenweg 20, 2300 RC, Leiden, The Netherlands 2. Institute for Molecular Cell Biology, University of Münster, Schlossplatz 5, 48149, Münster, Germany 3. The Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands |
| Abstract: | Bone morphogenetic proteins (BMPs) are important extracellular cytokines that play critical roles in embryogenesis and tissue homeostasis. BMPs signal via transmembrane type I and type II serine/threonine kinase receptors and intracellular Smad effector proteins. BMP signaling is precisely regulated and perturbation of BMP signaling is connected to multiple diseases, including musculoskeletal diseases. In this review, we will summarize the recent progress in elucidation of BMP signal transduction, how overactive BMP signaling is involved in the pathogenesis of heterotopic ossification and Duchenne muscular dystrophy, and discuss possible therapeutic strategies for treatment of these diseases. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |