Production of passive cutaneous anaphylaxis (PCA) and reversed PCA by rat IgE antibody in the mouse |
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| Authors: | M Harada M Nagata M Takeuchi |
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| Institution: | Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan. |
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| Abstract: | Although IgE antibody is generally characterized as a homocytotropic antibody, it has been well known for some time that mouse IgE antibody causes potent sensitization of rat skin for PCA. The present study clearly shows the reciprocal cross-sensitization of mouse skin with rat IgE molecules. PCA and RPCA were produced by rat IgE antibody in an inbred mouse strain. DS/Shi, though not in C3H/HeShi, C57BL/6JShi and BALB/cCrj strains. Sensitization of DS/Shi mouse skin for PCA with rat IgE antibody was comparable in sensitivity with that of rat skin, but lasted only for a short term in comparison with the long persistence in rat skin. |
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