Glutathione andγ -glutamyl cycle enzymes in rat mammary gland

Summary The main enzymes of theγ-glutamyl cycle during the lactogenic cycle in rat mammary gland were studied. A significant increase was found in all of them with the onset of lactogenesis. The effect of methionine sulfoximine on reduced glutathione concentration was studied in tissue slices of lactating mammary gland. The findings suggest that this compound affects glutathione synthesis by inhibitingγ-glutamylcysteine synthetase. This work was supported by grant B1138-8223 from the Servicio de Desarrollo Cientifico, Universidad de Chile.