| 辛伐他汀对压力负荷下大鼠心肌骨桥蛋白表达的影响 |
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| 引用本文： | 肖蓬勃.辛伐他汀对压力负荷下大鼠心肌骨桥蛋白表达的影响[J].科学技术与工程,2010,10(28). |
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| 作者姓名： | 肖蓬勃 |
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| 作者单位： | 解放军第二十二医院内一科,格尔木,816000 |
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| 摘 要： | 研究辛伐他汀对压力负荷下大鼠心肌骨桥蛋白(OPN)的影响,将Sprague Dawley大鼠随机分为3组:假手术组(n=10)、模型组(n=10)和辛伐他汀组(n=10).腹主动脉缩窄术建立大鼠压力超负荷模型,8周后测定左室重量指数(LVWR)、B超检测左室游离壁厚度及室间隔厚度Westernblot检测心肌OPN表达水平.结果是①模型组和辛伐他汀组LVWR高于假手术组,辛伐他汀组LVWR低于模型组(P<0.01).②模型组和辛伐他汀组心肌OPN表达水平高于假手术组(P<0.01),辛伐他汀组低于模型组 (P<0.01).辛伐他汀能够减轻压力负荷引起的大鼠的心肌肥厚,其过程伴随着OPN水平的降低,提示辛伐他汀改善心脏功能的过程与OPN有关.
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| 关 键 词： | 辛伐他汀 骨桥蛋白 左室肥厚 |
| 收稿时间： | 2010/6/17 0:00:00 |
| 修稿时间： | 7/4/2010 9:10:15 PM |
Effects of simvastatin on OPN in rats undertaken pressure overload |
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| Xiao Pengbo.Effects of simvastatin on OPN in rats undertaken pressure overload[J].Science Technology and Engineering,2010,10(28). |
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| Authors: | Xiao Pengbo |
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| Institution: | XIAO Peng-bo,LIU Zheng-jian,LI Gao-yuan,ZHANG Xue-hong,ZHANG Yan(The 22th Hospital of the People's Liberation Army,Golmud 816000 P.R.China) |
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| Abstract: | Objective to investigate the effects of simvastatin on OPN in rats undertaken pressure overload.Methods Sprague-Dawley rats were randomly allocated into three groups:The sham-operated groups(n=10),model groups(n=10)and simvastatin-treated groups(n=10).The model of pressure overload rat was established by abdominal arota constriction.At the end of the treatment period,the left ventricular weight/body weight ratio,left ventricular mass,wall thickness(by echocardiography),myocardial content of OPN(by westernbl... |
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| Keywords: | Simvastatin OPN Hypertrophy left ventricular |
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