| 2,7-二氮螺[4.4]壬烷的合成 |
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| 引用本文： | 崔明祥 江致勤. 2,7-二氮螺[4.4]壬烷的合成[J]. 科学技术与工程, 2004, 4(1): 40-41 |
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| 作者姓名： | 崔明祥 江致勤 |
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| 作者单位： | 同济大学化学系,上海,200092;同济大学化学系,上海,200092 |
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| 基金项目： | 国家自然科学基金 ( 2 0 0 72 0 2 8)资助 |
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| 摘 要： | 以丙二腈为原料，经过亲核取代、水解环合、羰基还原系列反应，合成了2，7-二氮螺[4.4]壬烷。中间体及产物用质谱和核磁氢谱进行了结构表征。该方法改良了反应条件，简化了反应步骤，提高了产物收率。
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| 关 键 词： | 氮螺环 合成 改进 2 7-二氮螺[4.4]壬烷 |
| 文章编号： | 1671-1815(2004)04-0040-02 |
| 修稿时间： | 2003-09-28 |
Improved Synthesis of 2,7-Diazaspiro[4.4] Nonane |
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| CUI Mingxiang,JIANG Zhiqin. Improved Synthesis of 2,7-Diazaspiro[4.4] Nonane[J]. Science Technology and Engineering, 2004, 4(1): 40-41 |
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| Authors: | CUI Mingxiang JIANG Zhiqin |
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| Abstract: | Diazaspiro[4.4] nonane was synthesized from malononitrile as the starting material by a series of nucleleophilic displacement, hydrolytic cyclization and carbonyl reduction. The structures of the intermediates and product were characterized with 1H NMR and Mass spectra. This modified method has advantages of higher efficiency and better yield. |
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| Keywords: | azaspiro compound synthesis modification 2 7-Diazaspiro[4.4]nonane |
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