| 基于改进单纯形算法的药物动力学参数计算 |
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| 引用本文： | 刘利斌,张文,谢竹诚. 基于改进单纯形算法的药物动力学参数计算[J]. 浙江科技学院学报, 2007, 19(1): 4-6 |
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| 作者姓名： | 刘利斌 张文 谢竹诚 |
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| 作者单位： | 1. 广西民族大学,数学与计算机科学学院,南宁,530006
2. 东华理工学院,数学与信息科学学院,江西,抚州,344000 |
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| 基金项目： | 东华理工学院校长基金资助项目(DHYK0526) |
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| 摘 要： | 基于改进的单纯形算法和残数法,对药物动力学房室模型中的有关参数计算进行了研究。通过实例表明,将改进的单纯形算法和残数法相结合得到的混合算法其计算精度高、收敛速度快、具有很好的稳定性,而且该算法对初值的选取要求不高,故有一定的实用价值。
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| 关 键 词： | 药物动力学 房室模型 改进单纯形法 残数法 |
| 文章编号： | 24126126 |
| 修稿时间： | 2006-11-11 |
Pharmacokinetics Parameter Calculation Based on Improved Simplex Method |
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| LIU Li-bin,ZHANG Wen,XIE Zhu-cheng. Pharmacokinetics Parameter Calculation Based on Improved Simplex Method[J]. Journal of Zhejiang University of Science and Technology, 2007, 19(1): 4-6 |
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| Authors: | LIU Li-bin ZHANG Wen XIE Zhu-cheng |
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| Affiliation: | 1. College of Mathematics and Computer Science, Guangxi University for Nationalities, Nanning 530006, China; 2. College of Mathematics and Informational Science, East China Institute of Technology, Fuzhou 344000, China |
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| Abstract: | By using improved simplex method and residuals method,a calculation based on the parameters of compartment model of pharmacokinetics is presented.It is shown from numerical results that the accuracy of the combinative method of the former two methods is much better,the convergence rate faster,and the stability higher.Furthermore,the combinative method has little requirement on choosing initial value,thus it's very useful for our practice. |
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| Keywords: | pharmacokinetics compartment model improved simplex method residuals method |
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