Chromosome 3-linked frontotemporal dementia |
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Authors: | J Brown |
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Institution: | (1) Department of Neurology, P.O. Box 165, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ (UK), UK |
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Abstract: | Frontotemporal dementia accounts for a significant minority of all cases of presenile dementia. Many pedigrees have been
described in which frontotemporal dementia is inherited as an autosomal dominant trait. Frontotemporal dementia is genetically
heterogeneous with loci identified on chromosome 17 and chromosome 3. Clinical, pathological and genetic findings are described
in a large Danish family in which the disease gene lies in the pericentromeric region of chromosome 3. |
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Keywords: | , Frontotemporal dementia, Pick's disease, chromosome 3, |
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