| 激光粒度仪测定阿霉素纳米颗粒的粒径及粒径分布 |
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| 引用本文： | 吕凤娇,林华香,陈晓耕,许小平. 激光粒度仪测定阿霉素纳米颗粒的粒径及粒径分布[J]. 福州大学学报(自然科学版), 2006, 34(5): 751-754 |
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| 作者姓名： | 吕凤娇 林华香 陈晓耕 许小平 |
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| 作者单位： | 1. 福州大学化学化工学院,福建,福州,350002
2. 福建省省立医院,福建,福州,350001 |
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| 摘 要： | 以阿霉素为模型药物、N-乙烯基吡咯烷酮为单体,通过反相乳液聚合法制备了聚乙烯吡咯烷酮为载体的阿霉素抗癌纳米颗粒.用激光粒度仪测量了纳米颗粒的粒径大小和粒径分布,同时研究了乳化剂浓度、引发剂浓度、体系水量和反应温度对纳米颗粒尺寸的影响.
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| 关 键 词： | 阿霉素 纳米颗粒 激光粒度仪 粒径分布 |
| 文章编号： | 1000-2243(2006)05-0751-04 |
| 修稿时间： | 2005-07-22 |
Determination of doxorubicin - loaded nanoparticles size and size distribution with laser particle size instrument |
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| L Feng-jiao,LIN Hua-xiang,CHEN Xiao-geng,XU Xiao-ping. Determination of doxorubicin - loaded nanoparticles size and size distribution with laser particle size instrument[J]. Journal of Fuzhou University(Natural Science Edition), 2006, 34(5): 751-754 |
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| Authors: | L Feng-jiao LIN Hua-xiang CHEN Xiao-geng XU Xiao-ping |
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| Affiliation: | L(U) Feng-jiao,LIN Hua-xiang,CHEN Xiao-geng,XU Xiao-ping |
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| Abstract: | Doxorubicin-loaded nanoparticles,using doxorubicin as model drug and polyvinylpyrrolidone as matrix material,were prepared by inverse emulsion polymerization in this paper.The mean particle size and size distribution were measured by laser light scattering technique.The effect factors,such as the emulsifier,the initiator,the water and the temperature,on the size and the size distribution of doxorubicin-loaded nanoparticles were investigated. |
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| Keywords: | doxorubicin nanoparticle laser particle size instrument size distribution |
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