Nicotine and ascorbic acid effects on cold-restraint ulcers in rats |
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| Authors: | G B Glavin L Lagrotteria |
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| Institution: | (1) Department of Psychology, Brock University, L2S 3A1 St. Catharines, Ontario, Canada;(2) Department of Psychology, University of Winnipeg, R3B 2E9 Winnipeg, Manitoba, Canada |
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| Abstract: | Summary Rats were orally administered 1-ascorbic acid, nicotine, 1-ascorbic acid and nicotine, or distilled water for 10 days. Following
this treatment they were fasted for 24 h and then restrained in a cold environment for 2h. Nicotine alone produced significantly
more gastric ulcers than any other treatment. 1-Ascorbic acid increased ulceration relative to controls. The combined effects
of 1-ascorbic acid and nicotine resulted in reduced ulcer incidence and severity. It appears that 1-ascorbic acid and nicotine
do not act synergistically to augment stress-induced gastric ulcer.
Supported by Natural Sciences and Engineering Research Council of Canada grant No. A 6312. |
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