| 不同用量酒精对大鼠肝急性损伤的病检 |
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| 引用本文： | 刘红云,张福云,高福,覃彩芹.不同用量酒精对大鼠肝急性损伤的病检[J].孝感学院学报,2010,30(3):12-14. |
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| 作者姓名： | 刘红云 张福云 高福 覃彩芹 |
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| 作者单位： | 孝感学院,生命科学技术学院,湖北,孝感,432000 |
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| 基金项目： | 湖北省教育厅科学研究重大项目，孝感学院科研项目 |
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| 摘 要： | 将48只大鼠随机分成对照组和5个实验组,每组8只.实验组1～5组每只大鼠分别按体重4、8、13、16、20g/kg一次性灌胃47.5%酒精,对照组每只大鼠按体重20g/kg一次性灌胃生理盐水,灌胃后24h取肝组织进行病检.结果显示实验组各组炎细胞浸润、水变性均为100%,实验组3～5组脂肪变性、点状/片状坏死均为100%,而对照组未见异常病变,表明47.5%酒精摄入量在13g/kg以上可造成较严重的急性肝损伤.
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| 关 键 词： | 酒精 急性肝损伤 病理变化 |
Pathological Detection of Acute Liver Injury in Rats by Alcohol with Different Dose |
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| Liu Hongyun,Zhang Fuyun,Gao Fu,Qin Caiqin.Pathological Detection of Acute Liver Injury in Rats by Alcohol with Different Dose[J].JOURNAL OF XIAOGAN UNIVERSITY,2010,30(3):12-14. |
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| Authors: | Liu Hongyun Zhang Fuyun Gao Fu Qin Caiqin |
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| Institution: | Liu Hongyun,Zhang Fuyun,Gao Fu,Qin Caiqin(College of Life Science and Technology,Xiaogan University,Xiaogan,Hubei 432000,China) |
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| Abstract: | The pathological change of acute liver injury in rats by the alcohol with different dose was investigated.48 rats were randomly divided into the five experimental groups(eight rats/each group) and the control group(eight rats).The experimental groups were given the alcohol(47.5% v/v) at the dose of 4,8,13,16 and 20 g/kg body weight by gavages,and the control group was given the physiological saline.These rats were killed after 24h.Their hepatic tissues were examined by light microscope.The results indicated... |
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| Keywords: | alcohol acute liver injury pathological change |
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