The role of bystin in embryo implantation and in ribosomal biogenesis |
| |
Authors: | M N Fukuda M Miyoshi D Nadano |
| |
Institution: | (1) Cancer Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA;(2) Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa Nagoya, 464–8601, Japan |
| |
Abstract: | Human bystin was identified as a cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved
in human embryo implantation. Although the trophinin gene is unique to mammals, the bystin gene (BYSL) is conserved across eukaryotes. Recent studies show that bystin plays a key role during the transition from silent trophectoderm
to an active trophoblast upon trophinin-mediated cell adhesion. Bystin gene knockout and knockdown experiments demonstrate
that bystin is essential for embryonic stem cell survival and trophectoderm development in the mouse. Furthermore, biochemical
analysis of bystin in human cancer cells and mouse embryos indicates a function in ribosomal biogenesis, specifically in processing
of 18S RNA in the 40S subunit. Strong evidence that BYSL is a target of c-MYC is consistent with a role for bystin in rapid protein synthesis, which is required for actively growing
cells.
Received 30 June 2007; received after revision 7 August 2007; accepted 29 August 2007 |
| |
Keywords: | BYSL Enp1 ribosome embryo trophoblast placenta cancer |
本文献已被 PubMed SpringerLink 等数据库收录! |
|