| 一个新的糖衍生的尿烷型化合物的合成 |
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| 引用本文： | 李春葆,赵春常.一个新的糖衍生的尿烷型化合物的合成[J].天津大学学报(自然科学与工程技术版),1999,32(6):762-764. |
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| 作者姓名： | 李春葆 赵春常 |
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| 作者单位： | 天津大学理学院 |
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| 摘 要： | 醛１由ＮａＢＨ４和催化氢化得醇３，经Ｍｉｔｓｕｎｏｂｕ反应由３合成４，４用光气处理生成异氰酸酯５，在碱的作用下，糖肟６与５缩合生成７，用氨处理并用ＡｃＳＨ还原酰化得目标化合物９．从葡萄糖和醛１出发，经过１１步合成９，一个新的尿烷型化合物，所有的新化合物均由元素分析，红外光谱，核磁共振谱和质谱确定结构。
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| 关 键 词： | 葡萄糖 衍生物 丙烯醛 尿烷型化合物 合成 |
SYNTHESISOF A CARBOHYDRATE DERIVED URETHANE TYPE OF COMPOUND |
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| Li Chunbao,Zhao Chunchang,Li Nan,Wang Yonghui.SYNTHESISOF A CARBOHYDRATE DERIVED URETHANE TYPE OF COMPOUND[J].Journal of Tianjin University(Science and Technology),1999,32(6):762-764. |
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| Authors: | Li Chunbao Zhao Chunchang Li Nan Wang Yonghui |
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| Abstract: | Aldehyde 1 was rduced by NaBH 4 and catalytic hydrogenation to give alcohol 3.Mitsunobu reaction converted 3 into 4.Treatment of 4 with phosgene gave 5.Coupling of 6 with 5 produced 7 in the presence of NEt 3.Treatment of 7 with ammonium and then with AcSH resulted in 9.The new urethane type of compound 9 was synthesized in 11 steps from aldehyde 1 and D glucose.The structures of the new compounds were determined by elementary analysis,IR,NMR and MS. |
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| Keywords: | D glucose (E) 3 (2 nitrophenyl) propenal urethane type of compound |
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