| 盐酸倍他洛尔片溶出度测定方法研究 |
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| 引用本文： | 可钰,魏爱卿,张建业,张广明,刘宏民.盐酸倍他洛尔片溶出度测定方法研究[J].河南师范大学学报(自然科学版),2006,34(4):84-86. |
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| 作者姓名： | 可钰 魏爱卿 张建业 张广明 刘宏民 |
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| 作者单位： | 郑州大学,新药研究开发中心,郑州,450052;郑州大学,新药研究开发中心,郑州,450052;郑州大学,新药研究开发中心,郑州,450052;郑州大学,新药研究开发中心,郑州,450052;郑州大学,新药研究开发中心,郑州,450052 |
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| 基金项目： | 国家自然科学基金
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河南省重点攻关计划 |
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| 摘 要： | 建立了盐酸倍他洛尔片溶出度的UV测定方法,并研究了盐酸倍他洛尔片的溶出曲线.UV检测波长为274 nm,线性范围为40~140 mg.L-1,相关系数r=0.999 8;平均加样回收率为99.91%,RSD为0.35%;连续进样精密度8、h溶液稳定性的RSD分别为0.02%、0.04%.该方法简便、快速、准确度高.
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| 关 键 词： | 紫外可见分光光度法 盐酸倍他洛尔片 溶出度 |
| 文章编号： | 1000-2367(2006)04-0084-03 |
| 收稿时间： | 2005-02-28 |
| 修稿时间： | 2006-05-29 |
Studies on Dissolution Determination Method of Betaxolol Hydrochloride Tablets |
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| KE Yu,WEI Ai-qing,ZHANG Jian-ye,ZHANG Guang-ming,LIU Hong-min.Studies on Dissolution Determination Method of Betaxolol Hydrochloride Tablets[J].Journal of Henan Normal University(Natural Science),2006,34(4):84-86. |
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| Authors: | KE Yu WEI Ai-qing ZHANG Jian-ye ZHANG Guang-ming LIU Hong-min |
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| Abstract: | UV analytical method on dissolution test of betaxolol hydrochloride tablets was developed,and the dissolution curve of the tablets were also studied.The detective wavelength was 274 nm.The linear range(the absorbance value against to the concentration of betaxolol hydrochloride) was from 40 mg·L~(-1) to 120 mg·L~(-1),and the relative coefficient was(0.999 9).The average recovery of betaxolol hydrochloride was 99.91%,and its RSD was 0.35%.The RSDs of continuously detections and detections per 2 hours in 8 hours were 0.02% and 0.04% respectively.It is a simple,convenient,quick and accurate analytical method for the analysis of betaxolol hydrochloride. |
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| Keywords: | UV betaxolol hydrochloride tablets dissolution |
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