Depressor effects of muscarinic and non-muscarinic mediation induced by lateral hypothalamic stimulation in the cat |
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Authors: | B Blum J Israeli O Hart M Farchi |
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Affiliation: | Sackler School of Medicine, Dept. of Physiology and Pharmacology, Tel Aviv University, Israel. |
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Abstract: | Transient sympathetically-mediated depressor effects were induced by stimulation of a small locus in the lateral hypothalamic peri-fornical region, medial to the fields of Forel. The ganglionic blocking agent, atropine methyl nitrate (ATMN), was used to show that muscarinic as well as non-muscarinic sympathetic ganglion receptor neurotransmission was involved. Evidence is presented that stimulation of this LH site co-activates a number of mechanisms and that depending on which of these are activated, the ganglionic blocking agent ATMN may either block, reverse or potentiate the depressor effect. |
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