| 环磷酰胺化疗所致骨髓抑制的中药(寿胎丸)干预研究 |
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| 引用本文： | 古丽努尔·买买提,彭安,郑艳波,梁前进. 环磷酰胺化疗所致骨髓抑制的中药(寿胎丸)干预研究[J]. 北京师范大学学报(自然科学版), 2010, 46(4) |
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| 作者姓名： | 古丽努尔·买买提 彭安 郑艳波 梁前进 |
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| 作者单位： | 北京师范大学生命科学学院,基因工程药物及生物技术北京市重点实验室:100875,北京;新疆教育学院理学分院,830043,乌鲁木齐;北京师范大学生命科学学院,基因工程药物及生物技术北京市重点实验室:100875,北京;北京师范大学生命科学学院,北京师范大学医学研究院:100875,北京;中国医学科学院医药生物技术研究所,100050,北京 |
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| 基金项目： | 国家自然科学基金资助项目，细胞增殖及调控教育部重点实验室开放课题基金资助项目，北京市重点实验室基金资助项目 |
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| 摘 要： | 用骨髓有核细胞和白细胞计数的方法研究了化疗药物环磷酰胺(CTX)对小鼠骨髓的抑制作用和中药寿胎丸(FPP)的干预效应.结果表明: 1) CTX有明显的骨髓抑制作用,表现在骨髓有核细胞和外周血白细胞数量显著减少(P＜0.05);2) FPP对CTX所致的骨髓抑制有显著的干预效应,表现在明显减弱CTX骨髓抑制所造成的骨髓有核细胞和外周血白细胞数量的减少;3) 白细胞着丝粒蛋白B(CenpB)的表达水平与骨髓抑制及骨髓抑制干预效应明显相关(P＜0.05),可作为一种检测指标.
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| 关 键 词： | 环磷酰胺 寿胎丸 骨髓抑制 中药干预 着丝粒蛋白B(CenpB) |
INTERVENTION BY TRADITIONAL CHINESE MEDICINE (SHOUTAI WAN, FETUS PROTECTION PILL) AGAINST CYCLOPHOSPHAMIDE CHEMOTHERAPY SIDE EFFECT OF BONE MARROW SUPPRESSION |
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| GULINUER Maimaiti,PENG An,ZHENG Yanbo,LIANG Qianjin. INTERVENTION BY TRADITIONAL CHINESE MEDICINE (SHOUTAI WAN, FETUS PROTECTION PILL) AGAINST CYCLOPHOSPHAMIDE CHEMOTHERAPY SIDE EFFECT OF BONE MARROW SUPPRESSION[J]. Journal of Beijing Normal University(Natural Science), 2010, 46(4) |
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| Authors: | GULINUER Maimaiti PENG An ZHENG Yanbo LIANG Qianjin |
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| Affiliation: | GULINUER Maimaiti1,2) PENG An1,3) ZHENG Yanbo4) LIANG Qianjin1,3)(1)College of Life Sciences,Beijing Normal University,Beijing Key Laboratory of Gene Engineering Medicine and Biotechnology,100875,Beijing,China,2)Department of Science,Xinjiang Education Institute,830043,Urumchi,3)College of Life Sciences,Health Science Institute of Beijing Normal University: 100875,4)The Institute of Medical Biotechnology(IMB) of the Chinese Academy of Medical Sciences,100050,Bei... |
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| Abstract: | Bone marrow suppression after cyclophosphamide(CTX) chemotherapy and intervention by traditional Chinese medicine(Shoutai Wan,fetus protection pill,FPP) were studied.The results are as follows: 1)CTX distinctly suppressed bone marrow,resulting in reduced counts of nucleated bone marrow cells and leukocytes(P<0.05).2)FPP showed marked effect against bone marrow suppression by CTX,with reduction in nucleated bone marrow cells and leukocytes counts diminished.3)Expression of centromere protein CenpB in leukocy... |
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| Keywords: | cyclophosphamide(CTX) Shoutai Wan(fetus protection pill FPP) bone marrow suppression traditional Chinese medicine intervention centromere protein B(CenpB) |
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