Activation of the carcinogen N-hydroxy-2-acetylaminofluorene by rat mammary peroxidase |
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Authors: | D L Reigh Melissa Stuart R A Floyd |
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Institution: | (1) Biomembrane Research Laboratory, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, 73104 Oklahoma City, Oklahoma, USA |
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Abstract: | Summary A peroxidase preparation from rat mammary gland parenchymal cells, a target tissue of arylamine carcinogens, was shown to activate the carcinogen N-hydroxy-2-acetylaminofluorene via a nitroxyl free radical intermediate to the more active carcinogens nitrosofluorene and N-acetoxy-2-acetylaminofluorene. Hydrogen peroxide, cumene hydroperoxide, and linoleic acid hydroperoxide were effective as substrates. The antioxidants ascorbate, propyl gallate and reduced glutathione prevented the free radical activation route. |
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