A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes |
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| Authors: | J Gubbay J Collignon P Koopman B Capel A Economou A Münsterberg N Vivian P Goodfellow R Lovell-Badge |
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| Affiliation: | Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK. |
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| Abstract: | A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains. |
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