Plasma motilin levels in duodenal ulcer and effect of a truncal vagotomy and hypoglycaemia

Summary The identical response of plasma motilin levels, in duodenal ulcer patients and healthy controls, to a test meal and insulin induced hypoglycaemia, fail to demonstrate any significant abnormalities in motilin release. The close correlation between blood glucose and motilin suggest a possible role of this new hormone in carbohydrate metabolism.This work was made possible by a generous grant by the Wellcome Trust. The authors are indebted to Dr P. Mitznegg, Department of Pharmacology, University of Erlangen-Nuremberg (Germany) for his encouragement and aid in the development of the plasma motilin assay.