| 国产口服头孢克罗胶囊药动学和生物利用度研究 |
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| 引用本文： | 陈晓岚,冠娴,熊冬生.国产口服头孢克罗胶囊药动学和生物利用度研究[J].河南科学,1997(3). |
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| 作者姓名： | 陈晓岚 冠娴 熊冬生 |
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| 作者单位： | 河南医科大学基础医学院，华南理工大学生物学院 |
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| 摘 要： | 头孢克罗（ｃｅｆａｃｌｏｒ）是第一代的头孢类抗菌素，因其副作用小，抗菌活性高，易于口服等优点受到临床上的欢迎。近期国内亦有研制开发，为考察国内药品的临床效果，本文对国产口服头孢克罗胶囊的药效学参数和生物利用度进行了研究。结果表明，国产胶囊与进口同类产品相比，药动学参数之间无显著性差异，Ｃｍａｘ为１４．１０±２．８６，ｔｍａｘ＝０．７６±０．２６，与Ｌｉｌｙ公司药物相比，相对生物利用度为１．０１±０．１５。
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| 关 键 词： | 头孢克罗 生物利用度 |
BIOAVAILABILITY COMPRASION BETWEEN DOMESTIC CEFALOR AND IMPORTED ONE |
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| Chen Xiaolan,Kou Xian,Xiong Dongsheng.BIOAVAILABILITY COMPRASION BETWEEN DOMESTIC CEFALOR AND IMPORTED ONE[J].Henan Science,1997(3). |
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| Authors: | Chen Xiaolan Kou Xian Xiong Dongsheng |
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| Institution: | Chen Xiaolan 1 Kou Xian 1 Xiong Dongsheng 2 |
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| Abstract: | The HPLC method for determining the cefaclor concentration of plasma was described in this paper. The pharmcokinetics parameters were measured and the relative bioavailabilities between domestic and imported cefaclor were compared. The results show that there are no notable difference existing among them. |
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| Keywords: | Cefadlor Pharmcokinetic Bioavailability |
| 本文献已被 CNKI 等数据库收录！ |
