The Gene Expression Profile of D-galactose Induced Aging Model Rat Using cDNA Microarray |
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| Authors: | Li Min Wang Gang Zhang Wei Wang Miqu Zhang Yizheng |
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| Institution: | College of Life Science, Sichuan University, Chengdu 610064, P.R.China;College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R.China |
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| Abstract: | In order to study the molecular mechanism of D galactose induced aging model, cDNA microarray is used to analyze gene expression profiles of both normal and D galactose induced aging model rats. D galactose induced aging model rats are injected with D galactose, while normal rats are injected with physiological saline as control. After 7 weeks, the two groups of rats are killed simultaneously. Their livers are harvested for genome wide expression analysis. D galactose treated rats showed changes in gene expression associated with increase or decrease in xenobiotic metabolism, protein metabolism and energy metabolism. |
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| Keywords: | cDNA microarray D galactose aging model rat |
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