含有环丙沙星高分子前药物的合成 |
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引用本文: | 连鸿丹,;叶艳秋,;董声雄. 含有环丙沙星高分子前药物的合成[J]. 莆田高等专科学校学报, 2008, 0(5): 54-57 |
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作者姓名: | 连鸿丹, 叶艳秋, 董声雄 |
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作者单位: | [1]湄洲湾职业技术学院化学工程系,福建莆田351254; [2]福州大学化学化工学院,福建福州350002 |
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基金项目: | 福建省科技厅重点项目(200610019) |
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摘 要: | 以抗菌药物-盐酸环丙沙星(CIPRO)代替传统的聚氨酯扩链剂,采用六亚甲基二异氰酸酯(HDI)、聚己内酯(PCL)为原料,通过典型的两步聚氨酯缩合反应,成功地将药物耦合到聚氨酯的骨架结构上,合成了环丙沙星-聚氨酯高分子前药物。研究了不同加料顺序对药物含量和平均分子量的影响。结果表明,合成的高分子前药物具有较高的药物含量、平均分子量和较窄的分散性。
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关 键 词: | 高分子前药物 环丙沙星 聚氨酯 |
Synthesis of Ciprofloxacin-Bonded Polymer Prodrug |
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Affiliation: | LIAN Hong-dan, YE Yan-qiu, DONG Sheng-xiong ( 1. Chemistry & Chemical Engineering Department, Meizhouwan Vocational & Technical Colloge, Putian Fujian 351254, China; 2. College of Chemistry & Chemical Engineering, Fuzhou University, Fuzhou Fujian 350002, China ) |
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Abstract: | Antibiotic drug, ciprofloxacin hydrochloride which replaces the traditional chain extender, has been successfully incorporated as a monomer into the polyurethane backbone structure via a classical two-step polyurethane condensation reaction with 1,6-hexane diisocyanate (HDI) and polycaprolactone diol (PCL). The sequential order of monomer feeding have been studied. The result shows the polyurethane-ciprofloxacin prodrug have high drug concentration, molecular weight and a relatively narrow polydispersity. |
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Keywords: | polymer prodrug ciprofloxacin polyurethane |
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