Facilitation or inhibition of memory by morphine: a question of experimental parameters |
| |
Authors: | W Classen C Mondadori |
| |
Institution: | (1) Biological Research Laboratories, Pharmaceutical Division, CIBA-GEIGY Ltd., CH-4002 Basel, (Switzerland) |
| |
Abstract: | Summary The effects of morphine on memory are highly controversial. According to some investigators post-trial injections of morphine facilitate memory. Others, however, have reported impairment of memory after morphine injections. To investigate the extent to which this may be due to different experimental parameters, foot-shock intensity and dosage of morphine were systematically varied in a passive-avoidance task. It was found that post-trial administration of medium and relatively high doses of morphine facilitate retention performance following moderate levels of foot-shock. Under other conditions of dose and shock intensity, the drug was not effective or even impaired retention.Results presented in part at the EBBS Meeting in Louvain-la-Neuve (Belgium), November 1980. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|