具有钛框架增强结构人工骨的降解规律

为了解决磷酸钙骨水泥(CPC)复合骨形态发生蛋白(BMP)植入体强度低的缺陷,提出了一种钛框架-CPC-BMP复合结构的人工骨,并通过长达半年的动物实验及后续分析研究其降解规律,得出了这种植入体降解的动力学模型.研究表明,CPC在植入动物体内后,其孔隙率按对数规律递增,靠近植入体表面的孔隙率明显低于其内部的孔隙率,植入体与骨接壤的端部界面因大块降解而呈现出中凸状的推进曲线,钛框架上小孔处的孔隙率明显高于无孔处的孔隙率.钛框架能有效提高植入体的整体强度,同时对CPC的整体降解速度没有明显影响,因此该复合植入体在大段骨修复中具有很高的临床应用价值.这些结论也为设计钛框架的形状提供了实验依据.

Degradation Mechanism of Calcium Phosphate Cement-Bone Morphogenetic Protein Artificial Bone with Ti Frame Enhanced Structure

A new artificial bone composed of calcium phosphate cement (CPC)-bone morphogenetic protein (BMP)-titanium frame is proposed to improve the strength of CPC-BMP. An animal experiment of half a year and the succeeding research motivate a degrading model for this implant. The results confirm that the porosity of the implant increases logarithmically; the surface porosity is notably lower than the central porosity; the boundary between the two ports of the implant and fresh bone presents two bathtub curve because of a large phagedena degradation; the titanium frame can promote the strength of the implant without essentially slowing the holistic degradation and the implant can be expected to beemployed clinically in large bone repair. The conclusions provide an experimental basis for the titanium frame. .