Observations on the toxicity and metabolic relationships of polygodial,the chemical defense of the nudibranchDendrodoris limbata |
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Authors: | G. Cimino S. De Rosa S. De Stefano G. Sodano |
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Affiliation: | (1) Istituto per la Chimica di Molecole di Interesse Biologico del C.N.R., Via Toiano n.6, Arco Felice, I-80072 Napoli, (Italy) |
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Abstract: | Summary Polygodial (1), the defense metabolite stored in the skin of the nudibranchDendrodoris limbata, is toxic for the mollusc itself when injected into the hepatopancreas. Biosynthetic experiments using labeled mevalonic acid were devised to investigate a possible metabolic relationship between1 and the mixture of sesquiterpenoidic esters2, stored in the hepatopancreas. The results suggest that1 and2 are biosynthesized by independent pathways.Thanks are due to G. Villani for supplyingDendrodoris limbata and to A. Trabucco for technical assistance. |
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Keywords: | Polygodial chemical defense fish antifeedant nudibranchs Dendrodoris limbata biosynthesis marine natural products |
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