磁性蚯蚓纤溶酶脂质体的制备

用超声法将磁流体和蚯蚓纤溶酶同时包入脂质体中，形成一种具有磁导向性能的溶栓药物──磁性蚯蚓纤溶酶脂质体。纤溶酶包封率达80％以上。在磁场作用下该脂质体定向聚集在血栓周围，脂质体破坏后释放出来的纤溶酶可以将血栓完全溶解。还介绍了一种简便、快速制备磁流体的方法。本系统对于制备水溶性药物的磁性脂质体可能有一定通用性。

Preparation of Magnetic Lipsomes Encapsulating Fibrinolytic Enzymes of Earthworm

Magnetic fibrinolytic enzymes were prepared by encapsulation of both magnetite and earthw orm fibrinolytic enzymes in lipsomes made by ultrasonication. The efficiency of encapsulation was reached more than 8O%. The lipsomes could be localized and retained in the predetermined site (blood clot) by application of a permanent magnet.After the lipsomes being destroyed, the blood clot was totally dissolved by fibrinolytic enzymes released. The system used might become a common procedure for making magnetic lipsomes encapsulating aqueous medicine. A simple and rapid method for preparation of magnetite was also presented in the paper.