| 果蝇翅膀器官芽中Dpp 浓度梯度形成的数学模型 |
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| 引用本文： | 雷锦誌.果蝇翅膀器官芽中Dpp 浓度梯度形成的数学模型[J].科学通报,2010,55(11):984. |
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| 作者姓名： | 雷锦誌 |
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| 作者单位： | 清华大学周培源应用数学研究中心; |
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| 基金项目： | 国家自然科学基金资助项目(批准号:10601029) |
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| 摘 要： | Decapentaplgic(Dpp)是影响果蝇翅膀发育的重要成形素(morphogen)之一. 在果蝇胚胎发育的过程中, Dpp 在翅膀器官芽的前后轴(antero-posterior axis)附近产生, 通过某种未知的机制输运到翅膀器官芽的其他位置, 启动相应的信号转导通路, 控制目标位置细胞的生长发育. 通过反应扩散方程建立成形素通过细胞膜非受体(non-receptor)的协助从其局部合成区域扩散到远程作用区域的数学模型, 研究非受体对成形素浓度梯度形成的影响. 阐明了通过非受体协助的成形素输运机制, 可以形成既有生物学意义又对成形素超表达具有好的鲁棒性的浓度梯度.
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| 关 键 词： | 成形素 鲁棒性 反应扩散方程 数学模型 |
| 收稿时间： | 2009-09-17 |
Mathematical model of the Dpp gradient formation in drosophila wing imaginal disc |
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| LEI JinZhi Zhou Pei-Yuan Center for Applied Mathematics,Tsinghua University,Beijing ,China.Mathematical model of the Dpp gradient formation in drosophila wing imaginal disc[J].Chinese Science Bulletin,2010,55(11):984. |
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| Authors: | LEI JinZhi Zhou Pei-Yuan Center for Applied Mathematics Tsinghua University Beijing China |
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| Institution: | LEI JinZhi Zhou Pei-Yuan Center for Applied Mathematics,Tsinghua University,Beijing 100084,China |
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| Abstract: | Decapentaplgic (Dpp) is an important morphogen in the development of drosophila wing. During the development of drosophila, Dpp is synthesized near the antero-posterior axis of the wing imaginal disc, and transport to spread over the imaginal disc through a way that is not yet clear. In the target cells, Dpp binds to the receptor to form signaling molecules to regulate the expression of target genes, which in turn control the development of the cells. This work establishes a mathematical model through a set... |
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| Keywords: | morphogen robustness reaction-diffusion equation mathematical model |
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