| 3-氮杂-A-homo-4a-雄烯-4-酮化合物的合成及体外抗肿瘤活性研究 |
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| 引用本文： | 姚秋翠,黄燕敏,林启福,刘亮,崔建国.3-氮杂-A-homo-4a-雄烯-4-酮化合物的合成及体外抗肿瘤活性研究[J].广西师范学院学报(自然科学版),2011,28(4):46-50. |
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| 作者姓名： | 姚秋翠 黄燕敏 林启福 刘亮 崔建国 |
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| 作者单位： | 广西师范学院化学与生命科学学院,广西南宁,530001 |
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| 基金项目： | 广西教育厅项目(200507182) |
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| 摘 要： | 当在甾体化合物中引入氮原子或含氮官能团后,所得化合物的生物活性会明显提高。用酮经过酯化、肟化、重排、水解等反应合成3-氮杂-A-homo-4a-雄烯-4-酮化合物,并用六种人体肿瘤细胞珠对所合成化合物进行体外抗肿瘤活性的研究。
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| 关 键 词： | 睾酮 3-氮杂-A-homo-4a-雄烯-4-酮化合物 合成 抗肿瘤活性 |
Synthesis and Antitumor Activities of 3-aza-A-homo-4a-androstene-4-one |
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| YAO Qiu-cui,HUANG Yan-min,LIN Qi-fu,LIU Liang,CUI Jian-guo.Synthesis and Antitumor Activities of 3-aza-A-homo-4a-androstene-4-one[J].Journal of Guangxi Teachers Education University:Natural Science Edition,2011,28(4):46-50. |
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| Authors: | YAO Qiu-cui HUANG Yan-min LIN Qi-fu LIU Liang CUI Jian-guo |
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| Institution: | (College of Chemistry and Life Science,Guangxi Teachers Education University, Nanning,China,530001) |
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| Abstract: | The introduction of heteroatom or the replacement of one or more carbon atoms in steroidal molecule by a heteroatom will affect the chemical properties of the steroidal molecule and often result in alteration of its biological activity.3-aza-A-homo-4a-androstene-4-one were synthesized and the antiactivities of the compounds were studied. |
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| Keywords: | testosterone 3-aza-A-homo-4a-androstene-4-one anactivities synthesis |
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