| Morris水迷宫训练诱导大鼠海马轴突重塑 |
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| 引用本文： | 梁荫基,宿宝贵,潘三强,韩辉,湛湘丽,吴盾. Morris水迷宫训练诱导大鼠海马轴突重塑[J]. 暨南大学学报(自然科学与医学版), 2009, 30(2) |
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| 作者姓名： | 梁荫基 宿宝贵 潘三强 韩辉 湛湘丽 吴盾 |
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| 作者单位： | 暨南大学医学院,人体解剖学教研室,广东,广州,510632 |
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| 摘 要： | 目的:观察Morris水迷宫训练后大鼠海马苔藓纤维分布的变化,探讨海马神经元轴突的可塑性.方法:2月龄雄性SD大鼠40只,随机分为水迷宫训练模型组20只,游水对照组20只.用Neo-Timm染色观察海马苔藓纤维的分布;免疫荧光组织化学方法检测海马微管相关蛋白tau-1的定位;Western blotting方法检测tau-1表达.结果:SD大鼠经6 d学习训练,其逃避潜伏期逐日缩短.与对照组大鼠相比,Neo-Timm染色显示模型组大鼠海马CA3区苔藓纤维延伸至锥体细胞层和起始层,tau-1免疫表达阳性产物除分布在透明层以外,锥体细胞层或起始层内有明显颗粒分布.Western blotting显示tau-1表达量增加.结论:结果表明Morris水迷宫训练可以诱导大鼠海马CA3区轴突的重塑,提示苔藓纤维系统可作为一个研究轴突重塑和认知关系的理想区域.
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| 关 键 词： | 记忆 轴突可塑性 Morris水迷宫 |
Hippocampal axons remodeling was induced by Morris water maze in rats |
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| LIANG Yin-ji,SU Bao-gui,PAN San-qiang,HAN Hui,ZHAN Xiang-li,WU Dun. Hippocampal axons remodeling was induced by Morris water maze in rats[J]. Journal of Jinan University(Natural Science & Medicine Edition), 2009, 30(2) |
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| Authors: | LIANG Yin-ji SU Bao-gui PAN San-qiang HAN Hui ZHAN Xiang-li WU Dun |
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| Affiliation: | Department of Anatomy;Medical College;Jinan University;Guangzhou 510632;China |
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| Abstract: | Aim:To explore the plasticity of hippocampal neuronal axons,we investigated the remodeling of hippocampal mossy fiber by Morris water maze training in rats. Methods: Male SpragueDawley rats,2 months were randomly divided into the model group(n=20) and the control group(n=20).The distribution of mossy fiber was study by Neo-Timm stain.The distribution of microtube-associated protein tau-1 in the hippocampus CA3 region was observed by immunofluorescence stain between two groups.Expression of tau-1 was identif... |
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| Keywords: | tau-1 |
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