苯并[a]芘生物标志物3-羟基苯并[a]芘研究进展

 苯并[a]芘(B[a]P)是卷烟烟气中的重要有害成分,其在人体内产生的代谢物3-羟基苯并[a]芘(3-OHB[a]P),可作为B[a]P接触生物标志物用于区分不同暴露剂量人群(如吸烟者和非吸烟者,职业暴露和普通人群)及预测可能的作用机制。本文对B[a]P的危害性、3-OHB[a]P来源及检测方法进行了综述;并从3-OHB[a]P研究存在的问题和现状出发,对其在感受烟气和普通人群中进行生物监测的应用进行了展望。

Research Progress in 3-Hydroxybenzo[a]pyrene-biomarker of Benzo[a]pyrene

Benzo[a]pyrene (B[a]P) is a main toxic chemical component with tobacco smoking, which is a carcinogen to humans according to the adequate evidence from animals. 3-hydroxybenzo[a]pyrene (3-OHB[a]P) is a biomarker of B[a]P exposure. 3-OHB[a]P could be used to distinguish the populations with different levels of exposure, such as smokers, nonsmokers, occupational exposure population, and general population, and to determine the differences in metabolism. The research progress in 3-OHB[a]P is reviewed. Firstly, the carcinogenicity of B[a]P is discussed. And then the source of 3-OHB[a]P as well as the determination method of 3-OHB[a]P are reviewed. The applications of 3-OHB[a]P in biological monitoring are elaborated in detail, including occupational exposure population, smoking population, and the general population. Starting from the exist problems and current research status on 3-OHB[a]P, the prospects for applying 3-OHB[a]P to the study of biological monitoring smokers and general population are analyzed.