Effect of aspirin and vitamins C and E on synovial rheumatoid arthritic and other cells |
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Authors: | E S Wilkins M G Wilkins |
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Institution: | (1) Department of Kinesiology, Simon Fraser University, V5A 1S6 Burnaby 2, B.C., Canada |
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Abstract: | Summary Normal and rheumatoid arthritic human synovial cells, normal rat muscle and bone cells, were cultured with combinations of aspirin (acetylsalicytic acid), vitamins C and E. Aspirin reduced percent growth of all cells by about 1/5 relative to controls. High vitamin C eradicated arthritic cells. In combinations, vitamin C was most important in eradicating arthritic cells. A low-aspirin, low-vitamin C combination was most effective in reducing arthritic cell populations, while having little effect on normal cells. Vitamin E retarded but did not prevent the action of vitamin C.Acknowledgment. This work was supported by NRC grant No. A 6445 to Dr Bhakthan, Department of Kinesiology, Simon Fraser University. |
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