H4SiW12O40/SiO2高效催化一锅法合成2-(1-苯胺基)苯甲基-环己酮 |
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引用本文: | 徐玉林,李红福,杨水金. H4SiW12O40/SiO2高效催化一锅法合成2-(1-苯胺基)苯甲基-环己酮[J]. 宝鸡文理学院学报(自然科学版), 2015, 0(4): 28-33 |
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作者姓名: | 徐玉林 李红福 杨水金 |
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作者单位: | 湖北师范学院 化学化工学院,稀有金属化学湖北省协同创新中心,湖北 黄石 435002;湖北师范学院 化学化工学院,稀有金属化学湖北省协同创新中心,湖北 黄石 435002;湖北师范学院 化学化工学院,稀有金属化学湖北省协同创新中心,湖北 黄石 435002 |
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基金项目: | 湖北省自然科学基金重点项目 |
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摘 要: | 目的合成2-(1-苯胺基)苯甲基-环己酮。方法在室温条件下,采用溶胶凝胶法合成H_4SiW_(12)O_(40)/SiO_2催化剂,高效催化环己酮、苯甲醛和苯胺的Mannich反应合成2-(1-苯胺基)苯甲基-环己酮。结果在n(苯甲醛):n(环己酮):n(苯胺)=1.0∶1.8∶1.8,反应温度为20℃,催化剂的用量占反应物料总质量的10%,反应时间为23h的最佳条件下,2-(1-苯胺基)苯甲基-环己酮的收率可达77.5%。结论 H_4SiW_(12)O_(40)/SiO_2是合成2-(1-苯胺基)苯甲基-环己酮的优良催化剂,整个反应体系具有条件温和、操作简单、对环境友好和催化剂可重复回收利用等优点。
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关 键 词: | H4 SiW12 O40/SiO2 催化合成 Mannich 反应 溶胶凝胶 |
Efficient one-pot synthesis of 2-(1-anilino)benzyl-cyclohexanone with H4SiW12 O40/SiO2 |
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Abstract: | Objective To synthesize 2-(1-anilino)benzyl-cyclohexanone.Methods A new environ-mental friendly catalyst,H4 SiW12 O40/SiO2 was prepared with sol-gel method.The catalyst exhibited excellent catalytic activities for the synthesis of 2-(1-anilino)benzyl-cyclohexanone via three-compo-nent Mannich reaction of aniline,benzaldehyde and cyclohexanone.Results The effects of reaction on the yield of 2-(1-anilino)benzyl-cyclohexanone were investigated and the optimum conditions were de-termined as follows:the molar ratio of benzaldehyde to cyclohexanone to aniline was n (benzaldehyde):n (cyclohexanone):n (aniline)= 1.0∶1.8∶1.8,reaction temperature was 20 ℃,the mass ratio of the catalyst to total reactant was 10%,and reaction time was 23 h,the yield of 2-(1-anilino)ben-zyl-cyclohexanone could reach 77.5%.Conclusion The results showed that the reaction catalyzed by H4 SiW12 O40/SiO2 has advantages of mild reaction conditions,simple operation,easy isolation and re-cyclable catalyst. |
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Keywords: | H4 SiW12 O40 catalytic synthesis Mannich reaction sol-gel |
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