Effect of des-Tyr1-γ-endorphin on serotonin metabolism in rat brain regions |
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| Authors: | M Kurachi D H G Versteeg J M Van Ree H G M Westernberg H M Van Praag |
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| Institution: | (1) Department of Psychiatry and Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Vondellaan 6, NL-3521 GD Utrecht, (The Netherlands);(2) Present address: Department of Neuropsychiatry, Kanazawa University School of Medicine, Kanazawa, Japan |
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| Abstract: | Summary Intracerebroventicular (i.c.v.) administration of des-Tyr1-γ-endorphin (0.1 and 1.0 μg) caused a decrease of the serotonin (5-HT) concentration of the hippocampus. The concentration
of 5-HIAA and the pargyline-induced alterations in 5-HT and 5-HIAA were not affected. No effects were noticed in other brain
regions.
Acknowledgement. The skilful technical assistance of Ms Henny de Vos Burchart-Lodewijks and Mrs H.A. Spierenburg and J.A.
Meijer is gratefully acknowledged. Des-Tyr1-γ-endorphin was a gift of Dr. H.M. Greven, Organon International B.V., Oss, The Netherlands.
To whom reprint requests should be addressed. |
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