土槿皮对红色毛癣菌的抑菌作用及其超微结构的研究

采用药基混合法和液体稀释法对红色毛癣菌进行敏感性实验；观察药物作用下红色毛癣菌的超微结构变化．结果发现土槿皮水提物对红色毛癣菌菌丝有明显的抑制作用，抑菌效果与浓度呈正相关；最小抑菌浓度（MIC）为1mg／mL；透射电镜观察到药物作用下红色毛癣菌菌丝细胞壁明显增厚，细胞质及细胞器内部物质被降解，出现空腔，残留不规则膜结构，认为土槿皮对红色毛癣菌有强烈的抑制作用，有代替抗生素治疗皮肤癣症的应用潜力。

Study on Fungistasis Action and Ultrastructure of Pseudolarix kaempferi Gord

The Trichophyton rubum was cultured with the agar mixing method and liquid diluting method for antifungal sensitivity test; The ultralstructure of T.rubum in the process of Pseudolarix kaempferi Gord was studied by transmission electron microscope (TEM).The aqueous extract of P.kaempferi Gord was shown to have obvious action on T.rubum, and the antifungal effect was positively correlative with concentration; The minimal inhibitory concentration was 1 mg/mL; Observation under transmission electron microscope revealed that the hypha of T.rubum thickened obviously, the internal substances of cytoplasm and organelles were degraded, the empty cavity appeared and the irregular membraneous structure were resided in the cell. P.kaempferi Gord was found to possess intense action on T.rubum. This has practical potent of substituting antibiotic to cure ringworm of skin.