| 妥布霉素产生菌黑暗链霉菌F_(-211)发酵特性研究 |
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| 引用本文： | 洪文荣,孟春,石贤爱,刘致新.妥布霉素产生菌黑暗链霉菌F_(-211)发酵特性研究[J].福州大学学报(自然科学版),1998(5):106-109. |
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| 作者姓名： | 洪文荣 孟春 石贤爱 刘致新 |
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| 作者单位： | 福州大学生物与食品科学工程系，福州福益制药有限公司 |
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| 摘 要： | 从黑暗链霉菌Ｆ－２１１合成妥布霉素（Ｔｏｂｒａｍｙｃｉｎ）的发酵原理出发，研究黑暗链霉菌产生抗生素的特性，考察与生产妥布霉素紧密相关的种龄、周期、关键原料—油，和影响生物合成抗生素的各种主要因素，绘制出合理的发酵工艺控制图，优化发酵条件，使发酵单位提高了近一倍．
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| 关 键 词： | 妥布霉素 黑暗链霉素 发酵工艺 |
Study on the Fermentation Characteristic of Tobramycin by Streptomyces Tenebrarius |
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| Hong Wenrong,Meng Chun,Shi Xian′ai,Liu Zhixin.Study on the Fermentation Characteristic of Tobramycin by Streptomyces Tenebrarius[J].Journal of Fuzhou University(Natural Science Edition),1998(5):106-109. |
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| Authors: | Hong Wenrong Meng Chun Shi Xian′ai Liu Zhixin |
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| Institution: | 2 ( 1 Department of Biotechnology and Food Science, Fuzhou University, Fuzhou, 350002) ( 2 Fuzhou Fuyee Pharmaceutical Co. Ltd, Fuzhou, 350002) |
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| Abstract: | The main factors affecting tobramycin biosynthesis by Streptomyces tenebrarius were studied, suchas, the relation between titre and mycelium age of seed culture, fermentation hours, air ratio, key raw material (oil), density of mycelium, et. The microbiologic metabolism curve and the recommended operation conditions were plotted against fermentation age. After optimization of the fermentation conditions, the production of tobramycin was increased nearly double than the origin. |
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| Keywords: | tobramycin streptomyces tenebrarius fermentation |
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