AVP对VSMC脂质过氧化的影响及CGRP、SP的调节作用

目的：研究AVP对VSMC脂质过氧化的影响及CGRP、SP的调节作用。方法：以培养的大鼠血管平滑肌细胞（VSMC）为模型，动态观察了精氨酸加压素（AVP）对VSMC脂质过氧化的影响，及降钙素基因相关肽（CGRP）、P物质（SP）对AVP作用的调节，旨在探讨它们在高血压病发病中的意义。结果：（1）10－7M的AVP作用后，VSMP的丙二醛（MDA）含量明显高于对照组（P＜0．01）；（2）10－7M的CGRP、SP分别与10－7M的AVP共同作用后，VSMP的MDA含量均减少，与AVP对照组比较，差异非常显著（P＜0．01）。结论：AVP参与高血压病的发病与其致VSMC的脂质过氧化损伤有关，CGRP、SP对其有拮抗作用。

The study on the effects of AVP on VSMC lipid peroxidation and the regulation of CGRP and SP on AVP

Objective To study the effects of AVP on VSMC lipid peroxidation and the regulation of CGRP and SP on AVP. Method:Taking the cultured vascular smooth muscle cells (VSMC) of rats as the medel, we dynanlically observed the effects of arginine - vasopressin (AVP) on VSMC lipid Peroxidation and the regulation of calcitonin gene - ralated peptide (CGRP) and substance P (SP) so as to study the pathogenic effect of these factors on hypertension. ResultS: (1) Under the effects of 10 - 7 M of AVP, the content of MDN in VSMC was significantly higher than that in control group (P < 0 .01 ). (2) Under the effect of 10 -7 M of CGRP and SP together with 10 -7 M of AVP rpspectively , the content of MDA in VSMP were all decreased. Compared with the control group, the difference was significant (P < 0.01 ). Conclusion: The involvement of AVP in the formation of hypertension is asaseiated with the damage in VSMC lipid perokidation and CGRP and SP have antaponistic effect on AVP.