The interaction of organic cations with the mitochondrial membrane |
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| Authors: | S. Massari T. Pozzan |
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| Affiliation: | (1) C.N.R. Unit for the Study of Physiology of Mitochondria and Institute of General Pathology, University of Padova, Via Loredan 16, I-35100 Padova, (Italy) |
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| Abstract: | Summary Weak and strong organic bases behave in an opposite manner in respect to several mitochondrial functions. The former induce a catalytic exchange with K+ in valinomycon-treated, respiratory-inhibited mitochondria, and act as uncouplers in respiring mitochondria. The latter induce a stoicheometric exchange with K+ and are actively taken up by respiring mitochondria. |
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