The Ror receptor tyrosine kinase family |
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Authors: | WC Forrester |
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Institution: | (1) Department of Biology, Indiana University, 1001 East 3rd Street, Bloomington, Indiana 47405-3700 (USA), Fax: + 1 812 855 6705, e-mail: wforrest@bio.indiana.edu, US |
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Abstract: | Receptor tyrosine kinases (RTKs) participate in numerous developmental decisions. Ror RTKs are a family of orphan receptors
that are related to muscle specific kinase (MuSK) and Trk neurotrophin receptors. MuSK assembles acetylcholine receptors at
the neuromuscular junction 1, 2], and Trk receptors function in the developing nervous system (reviewed in 3-5]). Rors have
been identified in nematodes, insects and mammals. Recent studies have begun to shed light on Ror function during development.
In most species, Rors are expressed in many tissue types during development. Analyses of mutants that are defective in the
single nematode Ror demonstrate a role in cell migration and in orienting cell polarity. Mice lacking one of the two Ror gene
products display defects in bone and heart formation. Similarly, two different human bone development disorders, dominant
brachydactyly B and recessive Robinow syndrome, result from mutations in one of the human Ror genes.
Received 17 April 2001; received after revision 2 July 2001; accepted 4 July 2001 |
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Keywords: | , Cell migration, cell polarity, brachydactyly B, Robinow syndrome, bone development, |
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