Trichinella spiralis: Acceleration and inhibition of cyst calcification in rats |
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Authors: | A L Newsome J P Harley |
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Institution: | (1) Department of Biological Sciences, Eastern Kentucky University, 40475 Richmond, Kentucky, USA;(2) Present address: Dept of Biology, Memphis State University, 38152 Memphis, Tenn, USA |
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Abstract: | Summary Daily administration of vitamin D3 (75,000 IU/kg b.wt) for 7 days acceleratedTrichinella spiralis cyst calcification in rats with a 14-week-old infection. When disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) was administered (50 mg/kg b.wt) from 2 days before until 2 days after vitamin D3 treatment, cyst calcification was inhibited. Thus, the ability to inhibitT. spiralis calcification has been demonstrated for the first time.Supported in part by EKU faculty research grant No. 03-05.Much appreciation goes to Dr Gordon S. Hassings and the Proctor and Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio USA for providing the EHDP used in this study. |
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