| 以D-苯甘氨酸为原料的苯并咪唑类化合物的合成 |
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| 引用本文： | 艾林,郭胜男,申秀民.以D-苯甘氨酸为原料的苯并咪唑类化合物的合成[J].东北师大学报(自然科学版),2011,43(1):101-103. |
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| 作者姓名： | 艾林 郭胜男 申秀民 |
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| 作者单位： | 北京师范大学化学学院; |
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| 基金项目： | 国家自然科学基金资助项目(20602003); 北京师范大学青年基金资助项目 |
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| 摘 要： | 以D-苯甘氨酸为原料,经氨基保护和羧基活化后与邻苯二胺反应,以较高产率合成了苯并咪唑类化合物.通过1H NMR、13C NMR、IR和X射线衍射对其结构进行了表征.同时对其进行了旋光性测定,发现以D-苯甘氨酸为原料所合成的苯并咪唑类化合物发生了外消旋化作用.
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| 关 键 词： | D-苯甘氨酸 苯并咪唑类化合物 合成 |
An efficient synthesis of the benzimidazole derivative starting from D-phenylglycine |
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| AI Lin,GUO Sheng-nan,SHEN Xiu-min.An efficient synthesis of the benzimidazole derivative starting from D-phenylglycine[J].Journal of Northeast Normal University (Natural Science Edition),2011,43(1):101-103. |
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| Authors: | AI Lin GUO Sheng-nan SHEN Xiu-min |
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| Institution: | AI Lin,GUO Sheng-nan,SHEN Xiu-min(College of Chemistry,Beijing Normal University,Beijing 100875,China) |
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| Abstract: | The coupling of the activated N-hydroxysuccinimide ester of N-Cbz-D-phenylglycine with o-phenylenediamine afforded the benzimidazole derivative in good yield.This compound was charactered by 1H NMR,13C NMR,IR,and X-ray.In addition,the benzimidazole derivative was racemized in the reaction condition. |
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| Keywords: | D-phenylglycine benzimidazole derivative synthesis |
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